Drug Metabolism GRS – 2023
On July 8-9, 2023. Hannah Work presented a poster on her research work on HCV inhibitors.
Human Cytochrome P450 3A7 Binding Four Copies of Its Native Substrate Dehydroepiandrosterone 3-Sulfate
J Biol Chem. 2023 Jun 29:104993. doi: 10.1016/j.jbc.2023.104993. Online ahead of print. ABSTRACT Human fetal cytochrome P450 3A7 (CYP3A7) is involved in both xenobiotic metabolism… Read More »Human Cytochrome P450 3A7 Binding Four Copies of Its Native Substrate Dehydroepiandrosterone 3-Sulfate
Transcriptomics, metabolomics, and in-silico drug predictions for liver damage in young and aged burn victims
Commun Biol. 2023 Jun 2;6(1):597. doi: 10.1038/s42003-023-04964-2. ABSTRACT Burn induces a systemic response affecting multiple organs, including the liver. Since the liver plays a critical… Read More »Transcriptomics, metabolomics, and in-silico drug predictions for liver damage in young and aged burn victims
ASPET 2023
On May 18-21, 2023. The LAMPE Lab presented several of their research works in poster or talk format.
2023 International Conference on Cytochrome P450
In May 2023, Dr. Lampe was asked by Prof. Fred Guengerich to organize the 2027 International Conference on Cytochrome P450 (http://www.p450meetings.com/future/), which will be held right here in Denver, Colorado!
ISSX
In April 2023, Dr. Lampe was invited to join the International Society for the Study of Xenobiotics (ISSX: https://www.issx.org/) Biotransformation, Mechanisms, and Pathways Focus Group steering committee. Congratulations, Dr. Lampe!
Dalhousie University
On February 7th, 2023. Dr. Lampe gave a presentation in the Department of Pharmacology at Dalhousie University (https://medicine.dal.ca/departments/department-sites/pharmacology.html) in Newfoundland, Canada entitled, “Discovery and development of natural product and PROTAC-based inhibitors of the SARS-CoV-2 main protease, Mpro”.
Per- and polyfluoroalkyl substances (PFAS) inhibit cytochrome P450 CYP3A7 through direct coordination to the heme iron and water displacement
Per- and polyfluoroalkyl substances (PFAS) are a chemical class of highly stable, fluorinated compounds popular for use in a variety of consumer products. PFAS environmental… Read More »Per- and polyfluoroalkyl substances (PFAS) inhibit cytochrome P450 CYP3A7 through direct coordination to the heme iron and water displacement
