Rocky Mountain Discussion group
On September 29th, 2023. Dr. Lampe hosted the 2023 Annual Meeting of the Rocky Mountain Discussion group, with some fantastic speakers!
Consideration of Nevirapine Analogs To Reduce Metabolically Linked Hepatotoxicity: A Cautionary Tale of the Deuteration Approach
Idiosyncratic drug reactions (IDRs) in their most deleterious form can lead to serious medical complications and potentially fatal events. Nevirapine (NVP), still widely used in… Read More »Consideration of Nevirapine Analogs To Reduce Metabolically Linked Hepatotoxicity: A Cautionary Tale of the Deuteration Approach
Focus on Pharmacology
On September 25th, 2023. Dr. Lampe presented a talk at the ASPET Focus on Pharmacology series: Advances in Drug Metabolism, hosted by DMDD, entitled “CYP3A7’s Role in Parturition and Adverse Drug-hormone Interactions” (you can watch the recording here: https://youtu.be/AinWY0ef16A).
Lampe lab BBQ
Welcoming to 2 new lab members, Julieta Torres (Undergraduate student) and Abhinav Pentyala (Master student).
Drug Metabolism GRS – 2023
On July 8-9, 2023. Hannah Work presented a poster on her research work on HCV inhibitors.
Human Cytochrome P450 3A7 Binding Four Copies of Its Native Substrate Dehydroepiandrosterone 3-Sulfate
J Biol Chem. 2023 Jun 29:104993. doi: 10.1016/j.jbc.2023.104993. Online ahead of print. ABSTRACT Human fetal cytochrome P450 3A7 (CYP3A7) is involved in both xenobiotic metabolism… Read More »Human Cytochrome P450 3A7 Binding Four Copies of Its Native Substrate Dehydroepiandrosterone 3-Sulfate
Transcriptomics, metabolomics, and in-silico drug predictions for liver damage in young and aged burn victims
Commun Biol. 2023 Jun 2;6(1):597. doi: 10.1038/s42003-023-04964-2. ABSTRACT Burn induces a systemic response affecting multiple organs, including the liver. Since the liver plays a critical… Read More »Transcriptomics, metabolomics, and in-silico drug predictions for liver damage in young and aged burn victims
ASPET 2023
On May 18-21, 2023. The LAMPE Lab presented several of their research works in poster or talk format.
2023 International Conference on Cytochrome P450
In May 2023, Dr. Lampe was asked by Prof. Fred Guengerich to organize the 2027 International Conference on Cytochrome P450 (http://www.p450meetings.com/future/), which will be held right here in Denver, Colorado!
ISSX
In April 2023, Dr. Lampe was invited to join the International Society for the Study of Xenobiotics (ISSX: https://www.issx.org/) Biotransformation, Mechanisms, and Pathways Focus Group steering committee. Congratulations, Dr. Lampe!