J Biol Chem. 2024 Jul 18:107594. doi: 10.1016/j.jbc.2024.107594. Online ahead of print. ABSTRACT Drug metabolism is one of the main processes governing the pharmacokinetics and… Read More »Drug metabolism of ciprofloxacin, ivacaftor, and raloxifene by Pseudomonas aeruginosa cytochrome P450 CYP107S1
On July 07-10, 2024. Jed Lampe gave a research talk and Sylvie Kandel presented a poster.
On June 25th, 2024, Jed Lampe was appointed to the ASPET journal Drug Metabolism and Disposition editorial board.
On May 16-19, 2024. The LAMPE Lab presented several of their research works in poster or talk format.
The CYP3A7 enzyme accounts for ~50% of the total CYP content in fetal and neonatal livers and is the predominant CYP involved in neonatal xenobiotic… Read More »Comparison of the CYP3A selective inhibitors CYP3cide, clobetasol, and azamulin for their potential to distinguish CYP3A7 activity in the presence of CYP3A4/5
Hannah defended her thesis on April 12th, 2024.
On March 10-14, 2024, Michaela Hvizdak presented her research work on PFAS in a poster format.
The hepatitis C virus (HCV) poses a great risk to pregnant people and their developing fetus, yet no HCV antiviral treatment guidelines have been established.… Read More »HCV antiviral drugs have the potential to adversely perturb the maternal-fetal communication axis through inhibition of CYP3A7 DHEA-S oxidation
Drug Metab Dispos. 2024 May 16;52(6):516-525. doi: 10.1124/dmd.123.001434. ABSTRACT The hepatitis C virus (HCV) poses a great risk to pregnant people and their developing fetus,… Read More »HCV Antiviral Drugs Have the Potential to Adversely Perturb the Fetal-Maternal Communication Axis through Inhibition of CYP3A7 DHEA-S Oxidation
The Lampe lab volunteered at the Food Bank of the Rockies and had lunch at North County.