ASPET 2024
On May 16-19, 2024. The LAMPE Lab presented several of their research works in poster or talk format.
Comparison of the CYP3A selective inhibitors CYP3cide, clobetasol, and azamulin for their potential to distinguish CYP3A7 activity in the presence of CYP3A4/5
The CYP3A7 enzyme accounts for ~50% of the total CYP content in fetal and neonatal livers and is the predominant CYP involved in neonatal xenobiotic… Read More »Comparison of the CYP3A selective inhibitors CYP3cide, clobetasol, and azamulin for their potential to distinguish CYP3A7 activity in the presence of CYP3A4/5
Hannah’s PhD defense
Hannah defended her thesis on April 12th, 2024.
2024 SOT Meeting
On March 10-14, 2024, Michaela Hvizdak presented her research work on PFAS in a poster format.
HCV antiviral drugs have the potential to adversely perturb the maternal-fetal communication axis through inhibition of CYP3A7 DHEA-S oxidation
The hepatitis C virus (HCV) poses a great risk to pregnant people and their developing fetus, yet no HCV antiviral treatment guidelines have been established.… Read More »HCV antiviral drugs have the potential to adversely perturb the maternal-fetal communication axis through inhibition of CYP3A7 DHEA-S oxidation
HCV Antiviral Drugs Have the Potential to Adversely Perturb the Fetal-Maternal Communication Axis through Inhibition of CYP3A7 DHEA-S Oxidation
Drug Metab Dispos. 2024 May 16;52(6):516-525. doi: 10.1124/dmd.123.001434. ABSTRACT The hepatitis C virus (HCV) poses a great risk to pregnant people and their developing fetus,… Read More »HCV Antiviral Drugs Have the Potential to Adversely Perturb the Fetal-Maternal Communication Axis through Inhibition of CYP3A7 DHEA-S Oxidation
2023 Christmas Lampe lab lunch
The Lampe lab volunteered at the Food Bank of the Rockies and had lunch at North County.
Polymerization of Physisorbed Molecular Monolayers via Overhanging Alkynyl Chains: Characterization of Polymerization Kinetics and Monolayer Durability
Langmuir. 2023 Nov 21;39(46):16457-16471. doi: 10.1021/acs.langmuir.3c02277. Epub 2023 Nov 9. ABSTRACT Monolayers self-assembled by triphenyleneethynylene (TPE) compounds bearing two terminal alkynyl chains were polymerized by… Read More »Polymerization of Physisorbed Molecular Monolayers via Overhanging Alkynyl Chains: Characterization of Polymerization Kinetics and Monolayer Durability
Johns Hopkins University
On October 4th, 2023. Dr. Lampe presented a seminar in the Department of Pharmacology and Molecular Sciences, Johns Hopkins University, Baltimore (https://www.hopkinsmedicine.org/pharmacology-molecular-sciences), entitled: “Cytochrome P450 enzymes in the’pathobiome’: how Pseudomonas aeruginosa evades antibiotics through drug metabolism”
Correction: Human cytochrome P450 3A7 binding four copies of its native substrate dehydroepiandrosterone 3-sulfate
J Biol Chem. 2023 Sep 30;299(10):105283. doi: 10.1016/j.jbc.2023.105283. Online ahead of print. NO ABSTRACT PMID:37783037 | DOI:10.1016/j.jbc.2023.105283