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Jed LAMPE

Principal Investigator, Ph.D.

Dr. Jed Lampe is an R01-funded principal investigator, educator, and scientific leader in the ADME/DMPK field. After receiving his Ph.D. in Medicinal Chemistry from the University of Washington, he completed post-doctoral training at UCSF under the tutelage of Professor Paul Ortiz de Montellano, where he studied ligand binding dynamics and their relationship to enzyme function in cytochrome P450 enzymes using pioneering 2-dimensional NMR techniques with site-specifically incorporated unnatural amino acids. Currently, he serves as an Associate Professor in the Department of Pharmaceutical Sciences at the University of Colorado, Skaggs School of Pharmacy where his research interests involve the application of bioanalytical, biophysical, and computational techniques to understand and predict drug metabolism and disposition in the neonate and developing infant. He serves on a number of editorial boards, including: Current Drug Metabolism, PLOS One, Nature Scientific Reports, and the Journal of Drug Metabolism and Toxicology.

Jed

Education

Postdoctoral
Pharmaceutical Chemistry

University of California
San Francisco, CA

2010

Ph.D.
Medicinal Chemistry

University of Washington
Seattle, WA

2007

M.S.
Microbiology

Idaho State University
Pocatello, ID

1999

B.S.
Biological Sciences

Walla Walla University
Walla Walla, WA

1992

Representative publications

Drug metabolism of ciprofloxacin, ivacaftor, and raloxifene by Pseudomonas aeruginosa cytochrome P450 CYP107S1

Comparison of the CYP3A selective inhibitors CYP3cide, clobetasol, and azamulin for their potential to distinguish CYP3A7 activity in the presence of CYP3A4/5

HCV antiviral drugs have the potential to adversely perturb the maternal-fetal communication axis through inhibition of CYP3A7 DHEA-S oxidation

Characterization of fluorescent probe substrates to develop an efficient high-throughput assay for neonatal hepatic CYP3A7 inhibition screening

Inhibition of CYP3A7 DHEA-S Oxidation by Lopinavir and Ritonavir: An Alternative Mechanism for Adrenal Impairment in HIV Antiretroviral-Treated Neonates

Neonatal cytochrome P450 CYP3A7: A comprehensive review of its role in development, disease, and xenobiotic metabolism

Aqueous synthesis of a small-molecule lanthanide chelator amenable to copper-free click chemistry

Ligand-dependent modulation of hOCT1 transport reveals discrete ligand binding sites within the substrate translocation channel

Digging Deeper into CYP3A Testosterone Metabolism: Kinetic, Regioselectivity, and Stereoselectivity Differences between CYP3A4/5 and CYP3A7

Advances in the Understanding of Protein-Protein Interactions in Drug Metabolizing Enzymes through the Use of Biophysical Techniques

The role of hepatocyte nuclear factor 4-alpha in perfluorooctanoic acid- and perfluorooctanesulfonic acid-induced hepatocellular dysfunction

Analysis of cytochrome P450 CYP119 ligand-dependent conformational dynamics by two-dimensional NMR and X-ray crystallography