J Biol Chem. 2024 Jul 18:107594. doi: 10.1016/j.jbc.2024.107594. Online ahead of print. ABSTRACT Drug metabolism is one of the main processes governing the pharmacokinetics and… Read More »Drug metabolism of ciprofloxacin, ivacaftor, and raloxifene by Pseudomonas aeruginosa cytochrome P450 CYP107S1
The CYP3A7 enzyme accounts for ~50% of the total CYP content in fetal and neonatal livers and is the predominant CYP involved in neonatal xenobiotic… Read More »Comparison of the CYP3A selective inhibitors CYP3cide, clobetasol, and azamulin for their potential to distinguish CYP3A7 activity in the presence of CYP3A4/5
The hepatitis C virus (HCV) poses a great risk to pregnant people and their developing fetus, yet no HCV antiviral treatment guidelines have been established.… Read More »HCV antiviral drugs have the potential to adversely perturb the maternal-fetal communication axis through inhibition of CYP3A7 DHEA-S oxidation
Drug Metab Dispos. 2024 May 16;52(6):516-525. doi: 10.1124/dmd.123.001434. ABSTRACT The hepatitis C virus (HCV) poses a great risk to pregnant people and their developing fetus,… Read More »HCV Antiviral Drugs Have the Potential to Adversely Perturb the Fetal-Maternal Communication Axis through Inhibition of CYP3A7 DHEA-S Oxidation
J Biol Chem. 2023 Sep 30;299(10):105283. doi: 10.1016/j.jbc.2023.105283. Online ahead of print. NO ABSTRACT PMID:37783037 | DOI:10.1016/j.jbc.2023.105283
Idiosyncratic drug reactions (IDRs) in their most deleterious form can lead to serious medical complications and potentially fatal events. Nevirapine (NVP), still widely used in… Read More »Consideration of Nevirapine Analogs To Reduce Metabolically Linked Hepatotoxicity: A Cautionary Tale of the Deuteration Approach
J Biol Chem. 2023 Jun 29:104993. doi: 10.1016/j.jbc.2023.104993. Online ahead of print. ABSTRACT Human fetal cytochrome P450 3A7 (CYP3A7) is involved in both xenobiotic metabolism… Read More »Human Cytochrome P450 3A7 Binding Four Copies of Its Native Substrate Dehydroepiandrosterone 3-Sulfate
Commun Biol. 2023 Jun 2;6(1):597. doi: 10.1038/s42003-023-04964-2. ABSTRACT Burn induces a systemic response affecting multiple organs, including the liver. Since the liver plays a critical… Read More »Transcriptomics, metabolomics, and in-silico drug predictions for liver damage in young and aged burn victims
Per- and polyfluoroalkyl substances (PFAS) are a chemical class of highly stable, fluorinated compounds popular for use in a variety of consumer products. PFAS environmental… Read More »Per- and polyfluoroalkyl substances (PFAS) inhibit cytochrome P450 CYP3A7 through direct coordination to the heme iron and water displacement
Microbiol Spectr. 2022 Jun 22:e0103922. doi: 10.1128/spectrum.01039-22. Online ahead of print. ABSTRACT Cephalexin and cefadroxil are oral first-generation cephalosporins used to treat methicillin-susceptible Staphylococcus aureus… Read More »Cefadroxil Comparable to Cephalexin: Minimum Inhibitory Concentrations among Methicillin-Susceptible Staphylococcus aureus Isolates from Pediatric Musculoskeletal Infections