Chem Res Toxicol. 2026 Mar 30. doi: 10.1021/acs.chemrestox.5c00468. Online ahead of print. ABSTRACT Craniofacial abnormalities account for roughly one-third of all congenital birth defects worldwide.… Read More »New Mechanistic Evidence for Perfluorodecanoic Acid (PFDA) Teratogenicity via CYP26A1-Mediated Retinoic Acid Metabolism and Signaling
Drug Metab Dispos. 2025 Oct 21;53(12):100184. doi: 10.1016/j.dmd.2025.100184. Online ahead of print. ABSTRACT The significance of the gut microbiome on drug metabolism has been demonstrated,… Read More »The anti-inflammatory drug celecoxib is metabolized by Pseudomonas aeruginosa CYP107S1 in vitro and in vivo
Drug Metab Dispos. 2025 Oct;53(10):100158. doi: 10.1016/j.dmd.2025.100158. Epub 2025 Sep 8. ABSTRACT COVID-19 remains a significant health threat, particularly to people over the age of… Read More »Mechanistic insights into human carboxylesterase 2 (CES2) inhibition by the CES1 prodrug substrate remdesivir
J Biol Chem. 2024 Jul 18:107594. doi: 10.1016/j.jbc.2024.107594. Online ahead of print. ABSTRACT Drug metabolism is one of the main processes governing the pharmacokinetics and… Read More »Drug metabolism of ciprofloxacin, ivacaftor, and raloxifene by Pseudomonas aeruginosa cytochrome P450 CYP107S1
The CYP3A7 enzyme accounts for ~50% of the total CYP content in fetal and neonatal livers and is the predominant CYP involved in neonatal xenobiotic… Read More »Comparison of the CYP3A selective inhibitors CYP3cide, clobetasol, and azamulin for their potential to distinguish CYP3A7 activity in the presence of CYP3A4/5
The hepatitis C virus (HCV) poses a great risk to pregnant people and their developing fetus, yet no HCV antiviral treatment guidelines have been established.… Read More »HCV antiviral drugs have the potential to adversely perturb the maternal-fetal communication axis through inhibition of CYP3A7 DHEA-S oxidation
Drug Metab Dispos. 2024 May 16;52(6):516-525. doi: 10.1124/dmd.123.001434. ABSTRACT The hepatitis C virus (HCV) poses a great risk to pregnant people and their developing fetus,… Read More »HCV Antiviral Drugs Have the Potential to Adversely Perturb the Fetal-Maternal Communication Axis through Inhibition of CYP3A7 DHEA-S Oxidation
J Biol Chem. 2023 Sep 30;299(10):105283. doi: 10.1016/j.jbc.2023.105283. Online ahead of print. NO ABSTRACT PMID:37783037 | DOI:10.1016/j.jbc.2023.105283
Idiosyncratic drug reactions (IDRs) in their most deleterious form can lead to serious medical complications and potentially fatal events. Nevirapine (NVP), still widely used in… Read More »Consideration of Nevirapine Analogs To Reduce Metabolically Linked Hepatotoxicity: A Cautionary Tale of the Deuteration Approach
J Biol Chem. 2023 Jun 29:104993. doi: 10.1016/j.jbc.2023.104993. Online ahead of print. ABSTRACT Human fetal cytochrome P450 3A7 (CYP3A7) is involved in both xenobiotic metabolism… Read More »Human Cytochrome P450 3A7 Binding Four Copies of Its Native Substrate Dehydroepiandrosterone 3-Sulfate