Lab hike near Boulder foothills
Practicing social distancing and wearing all our face masks.
Merger of Whole Cell Biocatalysis with Organocatalysis Upgrades Alcohol Feedstocks in a Mild, Aqueous, One-Pot Process
Biosynthetic methods have the potential to deliver value-added chemicals from renewable feedstocks. However, despite major advances in metabolic engineering and synthetic biology, the rapid engineering… Read More »Merger of Whole Cell Biocatalysis with Organocatalysis Upgrades Alcohol Feedstocks in a Mild, Aqueous, One-Pot Process
Nutrimetabolomics reveals food-specific compounds in urine of adults consuming a DASH-style diet
Although health benefits of the Dietary Approaches to Stop Hypertension (DASH) diet are established, it is not understood which food compounds result in these benefits.… Read More »Nutrimetabolomics reveals food-specific compounds in urine of adults consuming a DASH-style diet
Neonatal cytochrome P450 CYP3A7: A comprehensive review of its role in development, disease, and xenobiotic metabolism
The human cytochrome P450 CYP3A7, once thought to be an enzyme exclusive to fetal livers, has more recently been identified in neonates and developing infants… Read More »Neonatal cytochrome P450 CYP3A7: A comprehensive review of its role in development, disease, and xenobiotic metabolism
Active metabolites in drug development
It is almost a decade since the second edition of the Handbook of Drug Metabolism was published. Since its inception, the goal of the Handbook… Read More »Active metabolites in drug development
Aqueous synthesis of a small-molecule lanthanide chelator amenable to copper-free click chemistry
The lanthanides (Ln3+), or rare earth elements, have proven to be useful tools for biomolecular NMR, X-ray crystallographic, and fluorescence analyses due to their unique… Read More »Aqueous synthesis of a small-molecule lanthanide chelator amenable to copper-free click chemistry
Ligand-dependent modulation of hOCT1 transport reveals discrete ligand binding sites within the substrate translocation channel
The human hepatic organic cation transporter 1 (hOCT1) is a well-known transporter of both xenobiotic and endogenous cations. The substrates and inhibitors of hOCT1 are… Read More »Ligand-dependent modulation of hOCT1 transport reveals discrete ligand binding sites within the substrate translocation channel
4-Methylpyrazole protects against acetaminophen hepatotoxicity in mice and in primary human hepatocytes
Liver injury due to acetaminophen (APAP) overdose is the major cause of acute liver failure in the United States. While treatment with N-acetylcysteine is the… Read More »4-Methylpyrazole protects against acetaminophen hepatotoxicity in mice and in primary human hepatocytes
Modulation of O-GlcNAc Levels in the Liver Impacts Acetaminophen-Induced Liver Injury by Affecting Protein Adduct Formation and Glutathione Synthesis
Overdose of acetaminophen (APAP) results in acute liver failure. We have investigated the role of a posttranslational modification of proteins called O-GlcNAcylation, where the O-GlcNAc… Read More »Modulation of O-GlcNAc Levels in the Liver Impacts Acetaminophen-Induced Liver Injury by Affecting Protein Adduct Formation and Glutathione Synthesis
Digging Deeper into CYP3A Testosterone Metabolism: Kinetic, Regioselectivity, and Stereoselectivity Differences between CYP3A4/5 and CYP3A7
The metabolism of testosterone to 6β-hydroxytestosterone (6β-OH-T) is a commonly used assay to evaluate human CYP3A enzyme activities. However, previous reports have indicated that CYP3A7… Read More »Digging Deeper into CYP3A Testosterone Metabolism: Kinetic, Regioselectivity, and Stereoselectivity Differences between CYP3A4/5 and CYP3A7