Representative publications
bioRxiv [Preprint]. 2026 Jul 27:2026.07.25.740721. doi: 10.64898/2026.07.25.740721. ABSTRACT The human opportunistic pathogen Pseudomonas aeruginosa produces copious quantities of the secondary metabolite pyocyanin (PYO). PYO has… Read More »Pseudomonas aeruginosa co-opts host antibiotic metabolism by pyocyanin induction of cytochrome P450 enzymes
Drug Metab Dispos. 2026 Apr 30;54(6):100314. doi: 10.1016/j.dmd.2026.100314. Online ahead of print. ABSTRACT Drug safety assessment in newborns is limited by ethical constraints and the… Read More »A CYP3A7 metabolically competent human induced pluripotent stem cell-derived hepatocyte-like cell (hHLC3A7) model for drug safety assessment in the newborn
Drug Metab Dispos. 2025 Dec;53(12):100188. doi: 10.1016/j.dmd.2025.100188. Epub 2025 Oct 22. ABSTRACT The drug discovery and development process faces significant challenges, including high attrition rates… Read More »Novel emerging cell and organoid systems for the study of drug metabolism and toxicity in humans
Langmuir. 2023 Nov 21;39(46):16457-16471. doi: 10.1021/acs.langmuir.3c02277. Epub 2023 Nov 9. ABSTRACT Monolayers self-assembled by triphenyleneethynylene (TPE) compounds bearing two terminal alkynyl chains were polymerized by… Read More »Polymerization of Physisorbed Molecular Monolayers via Overhanging Alkynyl Chains: Characterization of Polymerization Kinetics and Monolayer Durability
Idiosyncratic drug reactions (IDRs) in their most deleterious form can lead to serious medical complications and potentially fatal events. Nevirapine (NVP), still widely used in… Read More »Consideration of Nevirapine Analogs To Reduce Metabolically Linked Hepatotoxicity: A Cautionary Tale of the Deuteration Approach
Per- and polyfluoroalkyl substances (PFAS) are a chemical class of highly stable, fluorinated compounds popular for use in a variety of consumer products. PFAS environmental… Read More »Per- and polyfluoroalkyl substances (PFAS) inhibit cytochrome P450 CYP3A7 through direct coordination to the heme iron and water displacement
In the past two years, the COVID-19 pandemic has caused over 5 million deaths and 250 million infections worldwide. Despite successful vaccination efforts and emergency… Read More »Identification of Aloe-derived natural products as prospective lead scaffolds for SARS-CoV-2 main protease (Mpro) inhibitors
Biosynthetic methods have the potential to deliver value-added chemicals from renewable feedstocks. However, despite major advances in metabolic engineering and synthetic biology, the rapid engineering… Read More »Merger of Whole Cell Biocatalysis with Organocatalysis Upgrades Alcohol Feedstocks in a Mild, Aqueous, One-Pot Process